1) More cellular energy
a. Zhang J, Lv W, Zhang G, Zeng M, Cao W, Su J, Cao K, Liu J. Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome. Antioxid Redox Signal. 2024 Mar 20. doi: 10.1089/ars.2023.0339. Epub ahead of print. PMID: 38183629.
b. Murakami S, Kusano Y, Okazaki K, Akaike T, Motohashi H. NRF2 signalling in cytoprotection and metabolism. Br J Pharmacol. 2023 Sep 15. doi: 10.1111/bph.16246. Epub ahead of print. PMID: 37715470.
2) Better immune function
a. McCord JM, Gao B, Hybertson BM. The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review. Antioxidants (Basel). 2023 Feb 3;12(2):366. doi: 10.3390/antiox12020366. PMID: 36829925; PMCID: PMC9952775.
b. Pant T, Uche N, Juric M, Zielonka J, Bai X. Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases. Redox Biol. 2024 Apr;70:103077. doi: 10.1016/j.redox.2024.103077. Epub 2024 Feb 10. PMID: 38359749; PMCID: PMC10877431.
3) Stronger bones
a. Che J, Yang X, Jin Z, Xu C. Nrf2: A promising therapeutic target in bone-related diseases. Biomed Pharmacother. 2023 Dec;168:115748. doi: 10.1016/j.biopha.2023.115748. Epub 2023 Oct 20. PMID: 37865995.
b. Gambari L, Grigolo B, Grassi F. Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules. Front Endocrinol (Lausanne). 2022 Sep 15;13:937956. doi: 10.3389/fendo.2022.937956. PMID: 36187121; PMCID: PMC9521401.
c. Sun YX, Xu AH, Yang Y, Li J. Role of Nrf2 in bone metabolism. J Biomed Sci. 2015 Oct 29;22:101. doi: 10.1186/s12929-015-0212-5. PMID: 26511009; PMCID: PMC4625735.
d. Andrie KM, Palmer DR, Wahl O, Bork S, Campbell M, Walsh MA, Sanford J, Musci RV, Hamilton KL, Santangelo KS, Puttlitz CM. Treatment with PB125® Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs. Ann Biomed Eng. 2024 Mar;52(3):671-681. doi: 10.1007/s10439-023-03415-7. Epub 2023 Dec 3. PMID: 38044413.
3. Rahman FA, Hian-Cheong DJ, Thoms JP. Plants powering muscle: The effects of phytochemical PB125® on mitochondrial function and skeletal muscle health. J Physiol. 2023 Jun;601(11):2221-2223. doi: 10.1113/JP283779. Epub 2022 Nov 3. PMID: 36217772.
f. Musci RV, Andrie KM, Walsh MA, Valenti ZJ, Linden MA, Afzali MF, Bork S, Campbell M, Johnson T, Kail TE, Martinez R, Nguyen T, Sanford J, Wist S, Murrell MD, McCord JM, Hybertson BM, Zhang Q, Javors MA, Santangelo KS, Hamilton KL. Phytochemical compound PB125® attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline. J Physiol. 2023 Jun;601(11):2189-2216. doi: 10.1113/JP282273. Epub 2022 Aug 26. PMID: 35924591; PMCID: PMC9898472.
4) Improved molecular detoxification
a. Matsumaru D, Motohashi H. The KEAP1-NRF2 System in Healthy Aging and Longevity. Antioxidants (Basel). 2021 Nov 30;10(12):1929. doi: 10.3390/antiox10121929. PMID: 34943032; PMCID: PMC8750203.
b. Ngo V, Duennwald ML. Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease. Antioxidants (Basel). 2022 Nov 27;11(12):2345. doi: 10.3390/antiox11122345. PMID: 36552553; PMCID: PMC9774434.
5) Clearer thinking
a. Gray NE, Farina M, Tucci P, Saso L. The Role of the NRF2 Pathway in Maintaining and Improving Cognitive Function. Biomedicines. 2022 Aug 21;10(8):2043. doi: 10.3390/biomedicines10082043. PMID: 36009590; PMCID: PMC9405981.
b. Infantino V, Pappalardo I, Santarsiero A, Tripathi S, Singh G, de Oliveira MR. Brain Mitochondria as a Therapeutic Target for Carnosic Acid. J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053. PMID: 38538219.
6) Oxidant/antioxidant balance
a. Chun KS, Raut PK, Kim DH, Surh YJ. Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans. Free Radic Biol Med. 2021 Aug 20;172:699-715. doi: 10.1016/j.freeradbiomed.2021.06.031. Epub 2021 Jun 30. PMID: 34214633.
b. Aramouni K, Assaf R, Shaito A, Fardoun M, Al-Asmakh M, Sahebkar A, Eid AH. Biochemical and cellular basis of oxidative stress: Implications for disease onset. J Cell Physiol. 2023 Sep;238(9):1951-1963. doi: 10.1002/jcp.31071. Epub 2023 Jul 12. PMID: 37436042.