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        See our news about PB125 improving human blood vessel function in a new clinical study!

        The Pathways Bioscience PB125® dietary supplement was found to be ‘geroprotective’ in a mouse longevity study

        April 22, 2026

        Brooks Hybertson

        In a recent multi-University mouse longevity study our PB125® dietary supplement reduced age-related mortality risk. These recently published PB125® findings from the National Institute on Aging’s Interventions Testing Program (ITP) are very exciting to us because they provide independent validation of our own research showing that PB125® and Nrf2 activation support healthy aging!

        PB125® is a safe, potent Nrf2 activator containing active ingredients carnosol, withaferin A and luteolin. Derived from natural plants, these ingredients were extensively studied for their synergistic properties. Every ingredient and the final product undergo triple testing in Pathways Bioscience’s laboratory to ensure optimal quality and biological activity.
        Nrf2 factor controls the rate of production from hundreds of different genes that allow cells to survive under stressful conditions.
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        Based on the extensive amount of new, published scientific literature and our own research, we have identified at least five control points in Nrf2 activation...
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