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        See our news about PB125 improving human blood vessel function in a new clinical study!

        High standards key differentiator in supplements

        July 21, 2025

        Pathways Bioscience

        This is the latest in a series of articles exploring the factors that distinguish science-backed supplements, like PB125®, from those not supported by science.

        High standards are easy to promise but much harder to deliver, especially in the world of supplements.

        Today’s supplement industry is crowded by those not rigorously tested as a prevention or treatment for the conditions in which they are promoted, or even regulated, as highlighted in a recent Harvard article. As a result, knowing whether it’s safe – let alone effective – may be impossible to assess.

        Current State of the Industry

        In the U.S., dietary supplements are not subjected to the same testing and regulatory oversights as prescription medicines. This lack of regulation allows for a wide range of quality issues from mislabeled ingredients and ineffective formulas to contamination with harmful substances.

        In a market this vast and predominantly self-policed, the importance of high standards can’t be overstated. Unlike pharmaceuticals, which must undergo clinical trials and Food and Drug Administration processes before reaching consumers, supplements can be sold without prior evidence of safety or effectiveness. While manufacturers are responsible for ensuring their products meet basic quality standards, enforcement is limited and often reactive than preventative.

        What “High Standards” Really Means

        High standards for supplements ensure each dose delivers what the label claims every time. As well, standards bring order and credibility to a product, allowing customers to know it’s not only safe for consumption but also does what it claims it will.

        PB125® not only meets or exceeds GMP quality standards but also surpasses Pathways Bioscience’s own Nrf2 activity testing standards. Moreover, PB scientists and their academic collaborators have conducted – and continue to conduct – unmatched research on PB125 and its health benefits.

        The Risks of Low-Quality Supplements

        The existence of low-quality supplements in the marketplace that lack standards can pose myriad risks to consumers. The health risks can result from mislabeling, lack of effectiveness, unsafe ingredients and inappropriate dosages while the financial risk results from waste from paying for fillers or ineffective formulas.

        And while the reputational damage for brands may be inconsequential to some companies, the consumer impact is greater.

        At Pathways Bioscience, we believe what you put into your body matters. We hold ourselves to rigorous scientific and ethical standards. We operate with thorough testing and transparency, and we are committed to using well-studied ingredients and combinations that are backed by science and quality control processes.

        Benefits of Choosing High-Quality Supplements

        Choosing high-quality supplements is paramount for consumers, allowing for improved health outcomes, consistency in results and potency, building trust and loyalty in a product and giving professional credibility for health practitioners who prescribe the supplements.

        Consumers must be educated and vigilant in today’s supplement market and choosing science-backed products with high standards is a first step toward emphasizing industry accountability. Companies listen when bottom line is impacted.

        Investing in high-standard supplements is an investment in health and trust.

        PB125® is a safe, potent Nrf2 activator containing active ingredients carnosol, withaferin A and luteolin. Derived from natural plants, these ingredients were extensively studied for their synergistic properties. Every ingredient and the final product undergo triple testing in Pathways Bioscience’s laboratory to ensure optimal quality and biological activity.
        Nrf2 factor controls the rate of production from hundreds of different genes that allow cells to survive under stressful conditions.
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        Based on the extensive amount of new, published scientific literature and our own research, we have identified at least five control points in Nrf2 activation...
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